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The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.
Fu D, Samson LD, Hübscher U, van Loon B. Fu D, et al. DNA Repair (Amst). 2015 Nov;35:13-8. doi: 10.1016/j.dnarep.2015.09.008. Epub 2015 Sep 14. DNA Repair (Amst). 2015. PMID: 26408825 Free PMC article.
While ALKBH2 colocalizes with proliferating cell nuclear antigen (PCNA) in DNA replication foci, it remains unknown whether these two proteins alone form a complex or require additional components for interaction. ...Moreover, we find tha …
While ALKBH2 colocalizes with proliferating cell nuclear antigen (PCNA) in DNA replication foci, i …
Identification of a novel, widespread, and functionally important PCNA-binding motif.
Gilljam KM, Feyzi E, Aas PA, Sousa MM, Müller R, Vågbø CB, Catterall TC, Liabakk NB, Slupphaug G, Drabløs F, Krokan HE, Otterlei M. Gilljam KM, et al. J Cell Biol. 2009 Sep 7;186(5):645-54. doi: 10.1083/jcb.200903138. J Cell Biol. 2009. PMID: 19736315 Free PMC article.
Numerous proteins, many essential for the DNA replication machinery, interact with proliferating cell nuclear antigen (PCNA) through the PCNA-interacting peptide (PIP) sequence called the PIP box. ...Expression of an APIM peptide increase …
Numerous proteins, many essential for the DNA replication machinery, interact with proliferating cell nuclear antige …
CellTool: An Open-Source Software Combining Bio-Image Analysis and Mathematical Modeling for the Study of DNA Repair Dynamics.
Danovski G, Dyankova-Danovska T, Stamatov R, Aleksandrov R, Kanev PB, Stoynov S. Danovski G, et al. Int J Mol Sci. 2023 Nov 26;24(23):16784. doi: 10.3390/ijms242316784. Int J Mol Sci. 2023. PMID: 38069107 Free PMC article.
Importantly, CellTool provides a platform for easy implementation of custom image analysis packages written in a variety of programing languages. Using CellTool, we demonstrate that the ALKB homolog 2 (ALKBH2) demethylase is excluded from DNA damage sites despite recruitme …
Importantly, CellTool provides a platform for easy implementation of custom image analysis packages written in a variety of programing langu …